Does Wellbutrin Cause Insomnia?

Yes, insomnia is a known side effect of Wellbutrin (bupropion), particularly during the first few weeks of treatment.

Wellbutrin works by increasing levels of dopamine and norepinephrine in the brain — two neurotransmitters that play a role in energy, focus, and mood. While this can help reduce symptoms of depression, it may also lead to increased alertness or difficulty falling and staying asleep.

Why Does Wellbutrin Cause Insomnia?

Wellbutrin is chemically different from many other antidepressants. It has a stimulating effect on the central nervous system, which is helpful for people with low energy or fatigue associated with depression. However, this stimulant-like activity can also lead to:

• Restlessness
• Trouble falling asleep
• Frequent waking during the night

These effects are more common when:

• The medication is taken later in the day
• The dosage is increased too quickly
• The individual is more sensitive to stimulating medications

How to Manage Insomnia from Wellbutrin

If you’re experiencing insomnia while taking Wellbutrin, consider these tips:

1. Take the medication early in the day
   The earlier you take it, the less likely it is to interfere with your sleep cycle. Many providers recommend taking it in the morning.

2. Avoid caffeine and stimulants after 2 PM
   Combining Wellbutrin with other stimulants (like coffee, tea, or energy drinks) may worsen sleep issues.

3. Maintain good sleep hygiene

• Go to bed and wake up at the same time every day
• Avoid screens 1 hour before bedtime
• Keep your bedroom cool, quiet, and dark

1. Talk to your provider
   If insomnia continues for more than a few weeks, your provider might:

• Adjust your dose
• Switch to the Wellbutrin SR (sustained-release) or Wellbutrin XL (extended-release) version
• Recommend a different antidepressant if sleep issues persist

How Common Is Insomnia with Wellbutrin?

Clinical studies show that up to 11–20% of people taking Wellbutrin may experience insomnia, especially in the first few weeks. For many, the symptom lessens as the body adjusts to the medication.

Key Takeaway:

Wellbutrin can cause insomnia, especially if taken in the afternoon or evening. Adjusting your dose schedule and practicing good sleep habits can reduce this side effect. Always talk to your healthcare provider if sleep problems persist.