Neither Spravato nor ketamine infusion is universally “better.” The right option depends on your diagnosis, treatment history, cost, and how your body responds.
Key Differences Between Spravato and Ketamine Infusion
Spravato (esketamine) is an FDA-approved nasal spray used specifically for treatment-resistant depression (TRD) and major depressive disorder with suicidal thoughts. It must be administered in a certified medical clinic under supervision and is often covered by insurance.
Ketamine infusion uses racemic ketamine delivered intravenously. It is off-label but widely used for depression, anxiety, PTSD, and chronic pain. It typically works faster but is usually not covered by insurance.
When Spravato May Be Better
- You need an FDA-approved treatment
- Insurance coverage is important
- You prefer a structured, regulated treatment protocol
- You are being treated specifically for treatment-resistant depression
When Ketamine Infusion May Be Better
- You want faster symptom relief
- You have PTSD, anxiety, or chronic pain in addition to depression
- You have not responded to multiple antidepressants
- You can self-pay and want customized dosing
Effectiveness and Safety
Both treatments act on the NMDA receptor and can significantly reduce depressive symptoms. Ketamine infusions often show faster results, while Spravato offers a more standardized and regulated approach. Side effects for both may include dissociation, dizziness, nausea, and temporary increases in blood pressure.
Bottom Line
Spravato is better for patients seeking an FDA-approved, insurance-covered option, while ketamine infusions may be better for patients needing rapid relief or broader symptom treatment. A qualified mental health or medical provider can help determine the safest and most effective option for you.
At Insight Mental Wellness, we provide expert Spravato and ketamine infusion treatments for individuals struggling with treatment-resistant depression, anxiety, PTSD, and other mental health challenges. Our experienced team offers a safe, supervised, and personalized approach to help you find relief and improve your quality of life. Schedule your consultation today and take the first step toward a brighter, healthier future.