Spravato (esketamine) is a prescription nasal spray used to treat treatment-resistant depression and major depressive disorder with suicidal thoughts. It works differently from traditional antidepressants by targeting the NMDA receptor in the brain. The effects of Spravato are both physical and psychological, and the experience can vary from person to person.
🌟 Common Sensations During a Spravato Session:
- Dissociation: Many people report feeling detached from their body or surroundings. This may feel like you’re watching yourself from the outside or as though your thoughts are floating.
- Altered perception: You might notice changes in how you see or hear things. Lights might seem brighter, sounds may be distorted, or time may feel like it’s moving differently.
- Sedation and relaxation: Some individuals feel very calm or sleepy during the session.
- Emotional release: It’s not uncommon to experience a rush of emotions — some people cry, feel relief, or have moments of clarity.
- Euphoria or light-headedness: A feeling of mild euphoria or “high” may occur, though this isn’t the goal of treatment.
How long do the effects last?
- Effects usually begin within 30 to 40 minutes after the nasal spray is administered.
- The peak of the experience tends to occur around the 45-minute to 1-hour mark.
- Most sensations wear off within 1.5 to 2 hours, but you will be monitored for at least 2 hours at the clinic.
- You cannot drive yourself home — a trusted adult must accompany you.
Why do people feel this way?
Spravato rapidly increases glutamate in the brain, which may lead to changes in perception and mood. The altered state can help some patients explore emotions or thoughts that are otherwise hard to access. While it may feel unusual or intense, many describe it as a deep, introspective, and healing experience — especially when combined with talk therapy or supportive care.
Safety & Supervision
Spravato is only administered in certified healthcare settings. You will be closely monitored by trained professionals throughout your session to ensure your comfort and safety. Side effects are usually temporary and manageable.
In Summary:
Spravato often feels like a temporary altered state of consciousness — with dissociation, emotional shifts, and sensory changes. It’s not painful or frightening for most patients, and many find it therapeutic when supported by a professional care team.